NuviQue CaHA Combo Calcium filler 3 in 1

NuviQue CaHA Combo is a next-generation Calcium Hydroxyapatite (CaHA) biostimulator featuring a unique three-component system: CaHA + Recombinant Human Collagen (RH-Collagen) + Polynucleotide (PN).

Unlike conventional CaHA treatments that typically rely on saline for reconstitution, NuviQue CaHA Combo uses RH-Collagen and PN as functional diluents, creating a comprehensive approach to immediate structural support, collagen stimulation, and skin regeneration.

This triple-action formulation is designed to address multiple aspects of skin aging in a single treatment—helping restore volume and structural support while promoting progressive improvements in firmness, elasticity, texture, and overall skin quality.

Triple-Action Technology

1. Calcium Hydroxyapatite (CaHA) – 210 mg

CaHA microspheres act as a structural scaffold within the tissue, providing immediate support while encouraging the body’s natural collagen-production process.

Over time, the biodegradable CaHA particles are gradually broken down, while newly produced collagen helps maintain improved skin structure, firmness, and elasticity.

Key Functions:

• Provides immediate structural and volumizing support
• Stimulates natural collagen production
• Supports progressive tissue remodeling
• Helps improve firmness and elasticity
• Provides long-term biostimulatory benefits

2. Recombinant Human Collagen (RH-Collagen) 2.5ml

Instead of using an inactive saline diluent, NuviQue CaHA Combo incorporates Recombinant Human Collagen as an active component.

RH-Collagen provides immediate extracellular matrix support after treatment and helps bridge the period between initial treatment and the gradual collagen-stimulating effects of CaHA.

According to the product information, the RH-Collagen is structurally identical to human collagen and contains no animal-derived collagen components.

Key Functions:

• Provides immediate collagen and extracellular matrix support
• Helps improve skin firmness and elasticity
• Supports fibroblast activity and collagen synthesis
• Complements the gradual biostimulatory action of CaHA
• Helps create a supportive environment for tissue remodeling

3. Polynucleotide (PN) 2.5ml

PN complements CaHA and RH-Collagen by supporting the skin’s regenerative environment. It helps promote tissue recovery and cellular resilience while supporting regenerative signaling involved in overall skin renewal.

Key Functions:

• Supports skin regeneration and tissue repair
• Helps improve cellular resilience
• Supports regenerative signaling pathways
• Helps create a favorable environment for collagen remodeling
• Supports post-treatment recovery

Why Combine CaHA + RH-Collagen + PN?

The three components work at different stages of the skin-rejuvenation process.

Immediate Support – RH-Collagen + CaHA
CaHA provides a structural scaffold and volumizing support, while RH-Collagen immediately reinforces the extracellular matrix.

Progressive Collagen Stimulation – CaHA
Following treatment, CaHA microspheres stimulate fibroblast activity and encourage gradual production of new collagen.

Regenerative Support – PN
PN supports cellular renewal, tissue recovery, and the biological environment needed for effective skin remodeling.

Together, these mechanisms are designed to provide both immediate visible support and progressive improvement in skin quality over time.

Key Benefits

• Innovative CaHA + RH-Collagen + PN triple-action system
• Combines structural support, collagen stimulation, and regenerative care
• Uses functional RH-Collagen and PN diluents instead of conventional saline
• Provides immediate volumizing and structural support
• Stimulates gradual natural collagen production
• Helps improve skin firmness and elasticity
• Supports extracellular matrix remodeling
• Promotes smoother and healthier-looking skin
• Supports tissue regeneration and recovery
• Helps bridge the period between initial treatment and new collagen formation
• Designed for both immediate and progressive rejuvenation

How NuviQue CaHA Combo Works

Phase 1 – Immediate Structural Support

Immediately following treatment, CaHA provides a supportive scaffold, while RH-Collagen contributes additional extracellular matrix support. This combination helps provide an immediate improvement in tissue structure and volume.

Phase 2 – Collagen Remodeling

CaHA microspheres gradually stimulate fibroblast activity and new collagen formation. RH-Collagen complements this process by providing a supportive collagen-rich environment during the early remodeling stage.

Phase 3 – Regenerative Support

PN supports regenerative signaling and tissue recovery, helping maintain an optimal environment for ongoing collagen remodeling and overall skin rejuvenation.

The result is a multi-stage approach designed to deliver immediate support followed by progressive improvements in skin firmness, elasticity, and quality.

Advantages Over Conventional CaHA Systems

Traditional CaHA products may be diluted with normal saline depending on the treatment protocol. NuviQue CaHA Combo replaces conventional saline reconstitution with two functional components:

RH-Collagen → Immediate extracellular matrix and collagen support
PN → Regenerative and tissue-repair support
CaHA → Structural support and long-term collagen stimulation

This creates a more comprehensive biostimulation system within a single treatment protocol.

According to the product comparison information, results may continue for approximately 12–18 months, although treatment longevity and individual outcomes can vary.

Recommended Preparation

According to the manufacturer’s recommended protocol:

1. Introduce the RH-Collagen diluent into the CaHA vial.
2. Add the PN diluent sequentially.
3. Mix the components thoroughly.
4. Shake for approximately 15 minutes.
5. Allow the reconstituted solution to hydrate for approximately 15 minutes before use.

The manufacturer’s protocol indicates the use of a 27G needle with placement from the deep dermis to subcutaneous layer, depending on the treatment area and clinical objective.

Administration should be performed slowly and consistently. Gentle massage for approximately 1–2 minutes following treatment may be recommended according to the manufacturer’s protocol.

A treatment interval of approximately 4–6 weeks may be recommended when additional sessions are required.